21c Museum Hotel

Welcome to 21c Museum Hotel Louisville, where we redefine hospitality with a bold mix of contemporary art, Southern charm, and a passion for creating unforgettable stays! Nestled on historic West Main Street along Museum Row, our hotel is more than just a place to crash—it’s a 91-room boutique retreat, a world-class art museum, and the home of the acclaimed Proof on Main restaurant, all rolled into one. From the moment you spot our iconic red penguins and step into our gallery-inspired lobby, you’ll know you’re in for something extraordinary. We’re proud to be a Louisville original, blending the city’s rich heritage with a fresh, creative edge.

Our property sits in the beating heart of downtown Louisville, surrounded by the energy of Whiskey Row and the cultural treasures of Museum Row. Imagine sipping a bourbon at Proof on Main, where the vibe is lively and the flavors are locally sourced, then wandering through our 24/7 museum to marvel at thought-provoking art installations. With a $10 million refresh in 2024, we’ve taken our game to the next level—think sleek rooms, vibrant public spaces, and a commitment to showcasing the best of 21st-century creativity. Stay with us, and you’ll see why we’ve been named a top hotel in the South by Condé Nast Traveler readers time and again.

At 21c Museum Hotel Louisville, we’re all about immersing you in an experience that’s as unique as the city itself. Our team is here to make every moment seamless, from check-in to check-out, and our art-filled spaces spark curiosity around every corner. Whether you’re exploring nearby landmarks or kicking back in one of our plush rooms, this property is your gateway to Louisville’s soul. Here’s a closer look at what makes our hotel a standout choice for your next visit.

Hotel Features:

• 91 uniquely designed rooms blending historic charm with modern flair
• Multi-venue contemporary art museum open 24/7, free to guests and the public
• Housed in five restored 19th-century warehouses listed on the National Register of Historic Places
• Recently refreshed in 2024 with a $10 million renovation
• Pet-friendly accommodations (up to 75 lbs combined, fees apply—call us to confirm)
• Valet parking available ($34/day) with EV charging nearby
• 100% smoke-free property for a fresh, clean stay

Amenities:

• Complimentary Wi-Fi throughout the hotel—stay connected on us
• Luxurious bedding with custom linens and plush mattresses
• 50-inch HDTVs with cable and streaming options in every room
• Malin + Goetz bath amenities and quirky touches like rubber ducks
• Proof on Main: award-winning restaurant with a bourbon bar and local flavors
• 24-hour fitness center with cardio machines and free weights
• Spa services featuring sauna and massage treatments
• Over 11,000 square feet of event space, including a stunning atrium

Nearby Points of Interest:

• Louisville Slugger Museum & Factory (0.2 miles): Swing by for baseball history
• Muhammad Ali Center (0.3 miles): Celebrate the legend’s legacy
• Frazier History Museum (0.1 miles): Dive into Kentucky’s past
• Kentucky Science Center (0.4 miles): Fun for all ages with interactive exhibits
• Whiskey Row (0.2 miles): Taste bourbon where it all began
• KMAC Contemporary Art Museum (0.1 miles): More art just steps away
• Riverfront Park (0.5 miles): Stroll along the Ohio River

At 21c Museum Hotel Louisville, we’re not just a hotel—we’re a cultural hub where art, hospitality, and Louisville’s spirit collide. Come stay with us and discover why this property is a must-visit destination in the Bluegrass State!