21c Museum Hotel

Welcome to 21c Museum Hotel Louisville, where hospitality meets contemporary art and Southern charm. Located on historic West Main Street along Museum Row, our hotel is more than just a place to stay—it’s a 91-room boutique retreat, a world-class art museum, and home to the acclaimed Proof on Main restaurant. From the moment you encounter our signature red penguins and step into our gallery-inspired lobby, you’ll know you’re in for an unforgettable experience. We take pride in blending Louisville’s rich history with a fresh, creative edge, making every visit one-of-a-kind.

Located in the heart of downtown, our hotel places you within walking distance of Whiskey Row, museums, and cultural landmarks. Enjoy a handcrafted cocktail at Proof on Main, explore our 24/7 contemporary art museum, or unwind in one of our beautifully redesigned rooms. A recent $10 million renovation in 2024 has elevated our spaces with sleek, modern touches while preserving the charm of our historic building. It’s no surprise that Condé Nast Traveler readers consistently rank us among the top hotels in the South.

Our goal is to make your stay seamless and inspiring. Whether you’re visiting for business or leisure, our art-filled spaces, personalized service, and prime location ensure an exceptional experience. Here’s what makes 21c Museum Hotel Louisville a standout choice:

Hotel Features

• 91 uniquely designed rooms combining historic character with modern style
• A contemporary art museum open 24/7, free for guests and the public
• Located in five restored 19th-century warehouses listed on the National Register of Historic Places
• Recently updated in 2024 with a $10 million renovation
• Pet-friendly accommodations (up to 75 lbs combined, fees apply—call for details)
• Valet parking available ($34/day) with nearby EV charging
• 100% smoke-free property

Amenities

• Complimentary Wi-Fi throughout the hotel
• Luxurious bedding with custom linens and plush mattresses
• 50-inch HDTVs with cable and streaming options in every room
• Malin + Goetz bath amenities and playful touches like rubber ducks
• Proof on Main: award-winning restaurant and bourbon bar with locally inspired cuisine
• 24-hour fitness center with cardio machines and free weights
• Spa services, including sauna and massage treatments
• Over 11,000 square feet of event space, featuring a stunning atrium

Nearby Attractions

• Louisville Slugger Museum & Factory (0.2 miles) – Explore the history of baseball’s most iconic bat
• Muhammad Ali Center (0.3 miles) – Learn about the life and legacy of the boxing legend
• Frazier History Museum (0.1 miles) – Discover Kentucky’s fascinating past
• Kentucky Science Center (0.4 miles) – Interactive exhibits for all ages
• Whiskey Row (0.2 miles) – Experience Louisville’s famous bourbon culture
• KMAC Contemporary Art Museum (0.1 miles) – More art, just steps away
• Riverfront Park (0.5 miles) – Scenic walking paths along the Ohio River

Additional Details

• Check-in begins at 4:00 PM; check-out by 11:00 AM
• Guests must be 21+ to check in with a valid ID and credit card
• Breakfast available at Proof on Main (not included in room rate)
• Louisville International Airport is 6 miles away, about a 15-minute drive
• 24/7 front desk service for local recommendations and assistance
• Bike rentals available to explore the city
• Best rates guaranteed when booking directly on our website

At 21c Museum Hotel Louisville, we offer more than just a stay—we provide an immersive experience where art, culture, and hospitality come together. Book your visit and see why we’re a must-visit destination in the Bluegrass State.