Members-only rates
4.8 / 5 Excellent

Hampton Inn & Suites St. Louis/South I-55

Hampton Inn & Suites St. Louis/South I-55
Hampton Inn & Suites St. Louis/South I-55 – St. Louis, MO
Hampton Inn & Suites St. Louis/South I-55 – St. Louis, MO
Check in 3:00 PM
Check out 11:00 AM

About Hampton Inn & Suites St. Louis/South I-55

The Hampton Inn & Suites - Saint Louis South Interstate 55 is directly off Interstate 55, and 15 mi south of downtown St. Louis and its famous arch. Rooms at Hampton Inn & Suites - Saint Louis South Interstate 55 have flat-screen TVs. All rooms come furnished with a microwave, refrigerator, and work desk. A breakfast buffet is served every morning and newspapers are delivered to rooms at the Hampton Inn & Suites - Saint Louis South Interstate 55. Guests can relax in the indoor pool and spa bath after a long day or a workout in the hotel’s fitness center. The hotel offers many convenient amenities, such as a business center, an ATM/cash machine, and dry cleaning. The St. Louis Zoo is 30 minutes away from the Saint Louis South Interstate 55 Hampton Inn & Suites. The hotel is 25 mi away from Cahokia Mounds State Park, a UNESCO World Heritage site that features the largest pre-Columbian city in North America. One of the largest breweries in the world, the Anheuser-Busch Brewery, is 20 mi away.

Amenities

  • 24-hour front desk
  • Meeting space
  • Fitness center
  • On-site dining
  • Café / coffee shop
  • Business center
  • Express check-in / check-out
  • Concierge
  • Dry cleaning
  • Self-service laundry
  • Luggage storage
  • Full kitchen / kitchenette
  • In-room refrigerator
  • In-room microwave
  • Pool
  • Spa / sauna
  • Pet friendly
  • Family friendly
  • Wheelchair accessible
  • Public transit access
  • Airport shuttle
  • Smoke-free property
  • Air conditioning
  • Elevator

Reviews

4.8 / 5
Excellent 1002 reviews
  • Engine customer Jul 2026

    All the staff were so friendly. The ladies at breakfast (Kathy and Nancy) were so cheerful and helpful. These are the people who will make your day brighter. I like the bright room.

  • Engine customer Jul 2026

    There was security on property so you don't have to worry about your car being stolen or broken into. The hotel was clean and the staff was friendly. The rooms were nice as well I would definitely recommend

  • Engine customer Jul 2026

    The location was ideal. The security guy was on point every night. Breakfast was ok for hotel. The sheets on the bed were stained on the one bed. The housekeeper never came which isn't really an issue. One of the beds sounded like it was broken or breaking every time we would lay down.

  • Engine customer Jun 2026

    Very nice and comfortable

  • Engine customer Jun 2026

    Hotel was clean and the staff was polite and helpful. Breakfast was fair.

  • Engine customer Jun 2026

    Very spacious and clean room. Friendly staff and nice breakfast.

  • Engine customer Jun 2026

    Our room was immaculate and the staff was very friendly and helpful..... We had to leave....

  • Engine customer Jun 2026

    The food was not very good. Poor quality of food. Better quality of food.

  • Engine customer Jun 2026

    Check out staff great attitudes Check in staff. Terrible attitudes

  • Engine customer Jun 2026

    Very clean and comfortable

  • Engine customer Jun 2026

    By far the best hotel I’ve stayed in. Always so clean and friendly! There wasn’t anything I didn’t like.

  • Engine customer Jun 2026

    We stayed one night on our way back from Tulsa OK to Indianapolis. We were traveling with a small dog and needed space to walk her. We drove to area restaurants and stores and found them easily accessible without using the Interstate. The hotel was quiet and well kept, and the staff took care of our rather minor needs.

  • Engine customer Jun 2026

    Staff were helpful, and beds were great. Good breakfast selection, and the room was nice. Initially, our room stunk from cigarette smoke, and we requested another. This was not a problem, and the staff took care of this. An apology for the smoke, and she mentioned all rooms are non-smoking, which was not complied with by someone.

  • Engine customer Jun 2026

    My cousins and I were in town to see the Chicago Cubs play the St Louis Cardinals. This Hampton Inn & Suites was the perfect place to stay for the night. It is about a 20-minute Uber ride to the park but worked really well for us. It was very clean. The room was clean. The lobby was clean. The breakfast in the morning was very good and quite delicious. The lady who worked at breakfast, I did not catch her name, was so kind and sweet. I always look for clean hotels and this one definitely was great!

  • Engine customer Jun 2026

    The staff was very friendly and helpful. Our room was immaculate as well. We've stayed at this location several times and it's always a great experience. We had to leave

  • Engine customer Jun 2026

    The staff was attentive and so friendly. The hotel itself, room and amenities were all clean and updated. Nothing

  • Engine customer May 2026

    Bed was comfy, loved the shower, breakfast was good, & so very happy that y'all allow dogs!!! I wish the pet fee was a little cheaper, though. We have stayed there before & will definitely stay again!

  • Engine customer May 2026

    The parking and the room

  • Engine customer May 2026

    Every thing was great and will be back soon

  • Engine customer May 2026

    Parking was great, very close to all highways, staff super friendly, and room was great. Food not the best to me but I would stay here again.

Frequently asked questions about Hampton Inn & Suites St. Louis/South I-55

Does Hampton Inn & Suites St. Louis/South I-55 have free Wi-Fi?
Yes, Hampton Inn & Suites St. Louis/South I-55 offers free Wi-Fi for all guests. Free wired internet is also available in select rooms.
Does Hampton Inn & Suites St. Louis/South I-55 offer parking?
Yes, Hampton Inn & Suites St. Louis/South I-55 offers free parking on-site.
Does Hampton Inn & Suites St. Louis/South I-55 have meeting spaces, conference centers, or conference rooms?
Yes. Hampton Inn & Suites St. Louis/South I-55 features meeting spaces and dedicated conference rooms, suitable for corporate meetings and group gatherings. Banquet and reception facilities are also available.
Does Hampton Inn & Suites St. Louis/South I-55 have a fitness center?
Yes, Hampton Inn & Suites St. Louis/South I-55 features an on-site fitness center for guests. Additional wellness amenities include spa, pool.
Where is Hampton Inn & Suites St. Louis/South I-55 located, and how walkable is the area?
Hampton Inn & Suites St. Louis/South I-55 is located at 4200 Midamerica Lane, St. Louis, MO 63129. With a Walk Score of 43, the area is rated Car-Dependent. A car or rideshare is recommended for most trips in this area.

Why no public rates?

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