Hosting a Conference or Event in Florence

Among the top conference hotels in Florence you can book through Engine is the Hampton Inn & Suites Florence-North-I-95, whose largest event space, the Palmetto Ballroom, runs about 2,100 square feet and accommodates up to 238 people across 10 event spaces. Event planners, travel managers, and attendees booking their own rooms use this page to find properties with the meeting capacity their conference or corporate event requires. Search, compare, and book directly on Engine.

Florence sits at the intersection of I-95 and I-20 in South Carolina's Pee Dee region, drawing regional conferences, healthcare meetings, and corporate events to a city served by Florence Regional Airport. The hotels on this list accommodate organizations of every size and industry, whether your team is attending a trade show or hosting a multi-day training. You can search, compare, and book guest rooms at these properties on Engine; for a stay of 9 or more rooms, Engine Groups handles the room-block booking, and for 8 or fewer you book self-serve. Engine Spaces, Engine's meeting-and-event venue product, lets planners find and request meeting and event space across more than 40,000 venues.

Showing 15 properties (sorted by distance)

Hampton Inn & Suites Florence-North-I-95

2-star hotel 4.5 Excellent (964)

The Hampton Inn & Suites Florence-North-I-95 offers 10 event spaces and 136 guest rooms. Its largest event space, the Palmetto Ballroom, runs about 2,144 square feet and hosts up to 238 people.

  • Free breakfast avail.
  • Free parking avail.
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Hilton Garden Inn Florence

2-star hotel 4.3 Excellent (339)

With 11 event spaces and 186 rooms, the Hilton Garden Inn Florence gives planners flexibility for breakouts and sessions. The Grand Ballroom spans about 1,421 square feet and accommodates up to 150 people.

  • Free parking avail.
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Clarion Inn & Suites Florence - Darlington

2-star hotel 2.3 OK (413)

Clarion Inn & Suites Florence-Darlington features a Meeting Room of about 4,000 square feet that hosts up to 421 people. The property has 76 guest rooms.

  • Free breakfast avail.
  • Free parking avail.
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MainStay Suites Florence - Darlington

2-star hotel 2.3 OK (164)

MainStay Suites Florence-Darlington offers a Meeting Room running about 4,000 square feet with capacity for up to 421 attendees. The hotel has 107 rooms for overnight guests.

  • Free breakfast avail.
  • Free parking avail.
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Florence Express Inn

2-star hotel 3.0 Good (943)

Florence Express Inn has 96 guest rooms and one event space. The America's Best Value Inn Ballroom runs about 1,800 square feet and accommodates up to 100 people.

  • Free parking avail.
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Hyatt Place Florence Downtown

3-star hotel 4.5 Excellent (1003)

Hyatt Place Florence Downtown provides 2 event spaces and 103 guest rooms. Meeting Place 2, the larger of the two, spans about 945 square feet and holds up to 75 attendees.

  • Free breakfast avail.
  • Free parking avail.
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Homewood Suites by Hilton Florence

3-star hotel 4.2 Great (714)

Homewood Suites by Hilton Florence features The Florentine, a single event space of about 1,512 square feet that hosts up to 160 people. The property has 97 suites.

  • Free breakfast avail.
  • Free parking avail.
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TownePlace Suites by Marriott Florence

3-star hotel 4.5 Excellent (873)

TownePlace Suites by Marriott Florence has 89 suites and one Meeting Space running about 628 square feet. The space accommodates up to 50 people.

  • Free breakfast avail.
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Hampton Inn & Suites Florence Center

2-star hotel 4.5 Excellent (939)

Hampton Inn & Suites Florence Center offers 82 rooms and one event space. The Aycock Room spans about 525 square feet and holds up to 40 attendees.

  • Free breakfast avail.
  • Free parking avail.
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Florence Inn and Suites

2-star hotel 3.2 Good (500)

Florence Inn and Suites provides 2 event spaces and 51 guest rooms. Its largest room, HO JO, runs about 416 square feet and hosts up to 30 people.

  • Free parking avail.
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Comfort Suites Florence I-95

2-star hotel 4.0 Great (1008)

Comfort Suites Florence I-95 has 2 event spaces and 77 rooms. The Florence Meeting Room, its largest space, spans about 910 square feet and accommodates up to 101 people.

  • Free breakfast avail.
  • Free parking avail.
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Quality Inn & Suites Florence Civic Center

2-star hotel 3.8 Great (509)

Quality Inn & Suites Florence Civic Center offers 80 guest rooms and 2 event spaces. Its largest Meeting Room runs about 546 square feet with capacity for up to 56 attendees.

  • Free breakfast avail.
  • Free parking avail.
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La Quinta Inn & Suites by Wyndham Florence

3-star hotel 3.8 Great (2200)

La Quinta Inn & Suites by Wyndham Florence features 84 guest rooms and a Meeting Room of about 625 square feet. The space holds up to 25 people.

  • Free breakfast avail.
  • Free parking avail.
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Econo Lodge Florence - Darlington

2-star hotel 2.9 Good (1001)

Econo Lodge Florence-Darlington has 162 guest rooms and a Meeting Room running about 528 square feet. The space accommodates up to 56 attendees.

  • Free parking avail.
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Frequently asked questions

What should I compare when choosing among conference hotels in Florence?
Start with the largest event space each property offers and its capacity. For example, the Clarion Inn & Suites Florence-Darlington has a largest event space of about 4,000 square feet that can accommodate up to 421 people, while the Hampton Inn & Suites Florence-North-I-95 offers a Palmetto Ballroom running about 2,100 square feet for up to 238 people. Also consider the number of event spaces (helpful for breakout sessions) and the guest-room count to ensure everyone attending can stay on-site.
How does Engine help with both the guest rooms and the meeting space for a large event?
For the guest-room block, Engine Groups handles bookings of 9 or more rooms, while stays of 8 rooms or fewer are self-serve. For finding and requesting the meeting or event space itself, planners can use Engine Spaces, Engine's venue product that connects you to meeting and event venues. That way you can manage both pieces of your conference through one platform.
What makes a hotel a good fit for hosting a conference or large meeting?
Look for a property with enough event space to seat your expected attendance and enough guest rooms to house participants. The Hilton Garden Inn Florence, for instance, has 186 guest rooms and 11 event spaces with a largest space of about 1,400 square feet for up to 150 people. On-site amenities like catering and AV vary by property, so confirm those details when you request space.
How do attendees get to Florence for a conference?
Florence Regional Airport serves the city and offers convenient access for attendees flying in. Many of these hotels are near I-95, making them easy to reach by car as well. If you need lodging close to the airport, check each property's location when you search and compare options on Engine.
How does billing work when I book a large multi-room stay for a conference?
Engine offers consolidated invoicing so you receive one bill for the entire room block, along with multiple payment options to fit your organization's process. There's no membership fee to use the platform, and you get access to pre-negotiated rates across Engine's hotel network.

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